A2468
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A2468
Sigma
Atropine
meets USP testing specifications
| Synonym: | Hyoscyamine, Tropine tropate, endo-(±)-α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester |
| CAS Number: | 51-55-8 |
| Linear Formula: | C17H23NO3 |
| Molecular Weight: | 289.37 |
| Beilstein Registry Number: | 91260 |
| EC Number: | 200-104-8 |
| MDL number: | MFCD00022622 |
| PubChem Substance ID: | 24890659 |
Description
| Biochem/physiol Actions | Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors. |
Properties
| suitability | meets USP testing specifications |
| Gene Information | human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133) |
| rat ... Chrm1(25229), Chrm2(81645), Chrm3(24260), Drd2(24318), Htr1a(24473) | |
| mouse ... Chrm1(12669) |
Safety
References
| reference | Walch, L., et al., Evidence for a M1 muscarinic receptor on the endothelium of human pulmonary veins. Br. J. Pharmacol. 130, 73-78, (2000) |
| Zwart, R., and Vijverberg, H.P., Potentiation and inhibition of neuronal nicotinic receptors by atropine: competitive and noncompetitive effects. Mol. Pharmacol. 52, 886-895, (1997) | |
| Trovero, F., et al., Pharmacological profile of CEB-1957 and atropine toward brain muscarinic receptors and comparative study of their efficacy against sarin poisoning. Toxicol. Appl. Pharmacol. 150, 321-327, (1998) | |
| Merck | Merck 13,879 |
| Beilstein | Beil. 21,V,1,235 |
